The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and somewhat soluble in Alcoholic beverages. The molecular bodyweight is 406.37. Its molecular components is C18H21NO3•H3PO4 • ½ H2O, and it's got the following chemical framework.
Codeine is documented to show no proof of carcinogenicity or mutagenicity in a number of exam systems, such as the micronucleus and sperm abnormality assays and the Salmonella assay. Promethazine was nonmutagenic in the Salmonella test method of Ames.
Promethazine is often a phenothiazine spinoff which differs structurally in the antipsychotic phenothiazines from the presence of a branched facet chain and no ring substitution.
Promethazine is well absorbed through the gastrointestinal tract. Medical results are evident inside of 20 minutes soon after oral administration and generally previous 4 to 6 several hours, While They could persist assuming that 12 several hours.
Providing or making a gift of Promethazine Hydrochloride and Codeine Phosphate Oral Answer may hurt Other individuals, and is particularly against the legislation. Convey to your Health care company For those who have at any time abused or been depending on Alcoholic beverages, prescription medicines or street prescription drugs.
Head Damage And Greater Intracranial Force: The respiratory-depressant consequences of narcotic analgesics as well as their ability to elevate cerebrospinal fluid stress may very well be markedly exaggerated within the existence of head injuries, intracranial lesions or simply a preexisting increase in intracranial stress.
Codeine: A research in rats and rabbits described no teratogenic result of codeine administered during the period of organogenesis in doses starting from five to a hundred and twenty mg/kg. From the rat, doses within the one hundred twenty-mg/kg degree, in the poisonous array to the adult animal, were connected to an increase in embryo resorption at the time of implantation.
Codeine in oral therapeutic dosage won't typically exert big consequences to the cardiovascular method.
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It's not recognised whether Promethazine HCl is excreted in human milk. Mainly because a lot of drugs are excreted in human milk and due to the possible for severe adverse reactions in nursing infants from Promethazine HCl Oral Answer, a decision ought to be created irrespective of whether to discontinue nursing or to discontinue the drug, considering the importance of the drug for the mom.
Significant breathing challenges. Promethazine HCl Oral Resolution should not be Employed in patients with poor lung operate like Long-term check here obstructive lung disease or respiratory issues when sleeping (slumber apnea.)
Stimulation may very well be evident, particularly in young children and geriatric sufferers. Convulsions may well hardly ever arise. A paradoxical-variety response has actually been described in young children receiving one doses of seventy five mg to 125 mg orally, characterized by hyperexcitability and nightmares.
The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a little bit soluble in Alcoholic beverages.
Position the combination in a container such as a sealed plastic bag and throw it away inside the residence trash. You may as well adhere to your state or neighborhood tips regarding how to safely and securely toss away Promethazine Hydrochloride and Codeine Phosphate Oral Remedy.